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. 1997 Nov;65(11):4873-6.
doi: 10.1128/iai.65.11.4873-4876.1997.

Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults

C M Nguer  1 , T O Diallo, A Diouf, A Tall, A Dieye, R Perraut, O Garraud
Affiliations

Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults

C M Nguer et al. Infect Immun. 1997 Nov.

Abstract

This study shows markedly different isotype distributions of antibodies to asexual blood stages of Plasmodium falciparum and to merozoite surface protein 1 in clinically immune Senegalese adults depending on the study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where transmission is perennial compared to settings where it is seasonal. This suggests a role for antibody class and/or subclass production and utilization in the regulation of protective immunity to such antigens.

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