Review
doi: 10.1016/s0958-1669(97)80032-8.
Alphaviruses as expression vectors
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- PMID: 9353224
- DOI: 10.1016/s0958-1669(97)80032-8
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Review
Alphaviruses as expression vectors
Curr Opin Biotechnol.
1997 Oct.
Abstract
Alphavirus vectors have been used for efficient high-level expression of a variety of topologically different proteins, allowing studies of protein transport, localization and functional activity in a broad range of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology. Alphavirus vectors have also shown promising potential in vaccine production and preliminary gene therapy applications.
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