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Comparative Study
. 1997 Nov;17(3):280-4.
doi: 10.1038/ng1197-280.

Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

P Markel  1 , P Shu, C Ebeling, G A Carlson, D L Nagle, J S Smutko, K J Moore
Affiliations
Comparative Study

Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

P Markel et al. Nat Genet. 1997 Nov.

Abstract

Congenic breeding strategies are becoming increasingly important as a greater number of complex trait linkages are identified. Traditionally, the development of a congenic strain has been a time-consuming endeavour, requiring ten generations of backcrosses. The recent advent of a dense molecular genetic map of the mouse permits methods that can reduce the time needed for congenic-strain production by 18-24 months. We present a theoretical evaluation of marker-assisted congenic production and provide the empirical data that support it. We present this 'speed congenic' method in a user-friendly manner to encourage other investigators to pursue this or similar methods of congenic production.

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Comment in

  • Supersonic congenics?
    Behringer R. Behringer R. Nat Genet. 1998 Feb;18(2):108. doi: 10.1038/ng0298-108. Nat Genet. 1998. PMID: 9462736 No abstract available.

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