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. 1997 Nov;17(3):335-7.
doi: 10.1038/ng1197-335.

Quantitative trait loci analysis affecting contextual conditioning in mice

B Caldarone  1 , C Saavedra, K Tartaglia, J M Wehner, B C Dudek, L Flaherty
Affiliations

Quantitative trait loci analysis affecting contextual conditioning in mice

B Caldarone et al. Nat Genet. 1997 Nov.

Abstract

In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (lod scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with lod scores ranging from 1.8 to 2.7.

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  • Freeze!
    Flint J. Flint J. Nat Genet. 1997 Nov;17(3):250-1. doi: 10.1038/ng1197-250. Nat Genet. 1997. PMID: 9354776 No abstract available.

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