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Review
. 1997 Oct;18(10):478-82.
doi: 10.1016/s0167-5699(97)01127-4.

Th1-type immunity is incompatible with successful pregnancy

R Raghupathy  1
Affiliations
Review

Th1-type immunity is incompatible with successful pregnancy

R Raghupathy. Immunol Today. 1997 Oct.

Abstract

Several years ago, the rather provocative question was raised: is successful pregnancy a T helper 2 (Th2) phenomenon? Implicit in this argument is the corollary that unsuccessful pregnancy is a Th1-type situation. Here, evidence from murine and human pregnancy is presented to show that, since Th1-type cytokines mediate pregnancy loss, a shift towards Th1-type immunity may help resolve 'unexplained' pregnancy failure.

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