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. 1976 Jul 2;193(4247):70-2.
doi: 10.1126/science.935859.

Isolations of a cartilage factor that inhibits tumor neovascularization

R Langer, H Brem, K Falterman, M Klein, J Folkman

Isolations of a cartilage factor that inhibits tumor neovascularization

R Langer et al. Science. .

Abstract

A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.

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