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. 1976 Jul 23;193(4250):321-3.
doi: 10.1126/science.935869.

Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma

S B Baylin, D S Gann, S H Hsu

Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma

S B Baylin et al. Science. .

Abstract

A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.

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