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Clinical Trial
. 1976 May 22;50(22):849-51.

Effect of a histamine H2-receptor antagonist and an anticholinergic on gastric acid secretion in man

G O Barbezat, S Bank
  • PMID: 935972
Clinical Trial

Effect of a histamine H2-receptor antagonist and an anticholinergic on gastric acid secretion in man

G O Barbezat et al. S Afr Med J. .

Abstract

Metiamide (a histamine H2-receptor antagonist) and propantheline (an anticholinergic) are both inhibitors of gastric acid secretion. We have investigated the effect of gastric acid secretion of blocking the histamine and acetylcholine receptor sites separately and together. There was a statistically significant additive inhibitory effect on pentagastrin-stimulated volume secretion when both drugs were given together. The inhibition of acid output was slightly but insignificantly greater with the combination of drugs than when they were given separately.

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