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. 1997 Nov;4(11):900-3.
doi: 10.1038/nsb1197-900.

C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

J Brandsen, S Werten, P C van der Vliet, M Meisterernst, J Kroon, P Gros

C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

J Brandsen et al. Nat Struct Biol. 1997 Nov.

Abstract

The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.

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