Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Nov 14;278(5341):1309-12.
doi: 10.1126/science.278.5341.1309.

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

V Lacronique  1 , A Boureux, V D Valle, H Poirel, C T Quang, M Mauchauffé, C Berthou, M Lessard, R Berger, J Ghysdael, O A Bernard
Affiliations

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

V Lacronique et al. Science. .

Abstract

The Janus family of tyrosine kinases (JAK) plays an essential role in development and in coupling cytokine receptors to downstream intracellular signaling events. A t(9;12)(p24;p13) chromosomal translocation in a T cell childhood acute lymphoblastic leukemia patient was characterized and shown to fuse the 3' portion of JAK2 to the 5' region of TEL, a gene encoding a member of the ETS transcription factor family. The TEL-JAK2 fusion protein includes the catalytic domain of JAK2 and the TEL-specific oligomerization domain. TEL-induced oligomerization of TEL-JAK2 resulted in the constitutive activation of its tyrosine kinase activity and conferred cytokine-independent proliferation to the interleukin-3-dependent Ba/F3 hematopoietic cell line.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources