[Experimental studies concerning about the effects of the portal arterialization 4 weeks after ligation of hepatic artery under the optimal arterio-portal shunt blood flow]

Abstract

The changes of hepatic hemodynamics and hepatic oxygen metabolism after portal arterialization (APS) were studied. Beagle dogs were used for the experiments. Dogs were grouped as follows: group I (n = 6) had 2 days of APS, group II (n = 6) had 1 week of APS, group III (n = 6) had 4 weeks of APS. Portal arterialization performed by the anastomosis between the end of the hepatic artery and the hepatic portion of the side of the portal vein following ligation of the hepatic artery, the gastro-duodenal artery and the right gastric artery. It has been confirmed that arterio-portal shunt flow of this experimental model is the optimal arterio-portal shunt flow by the basic study. In all groups, total hepatic blood flow increased more than about 120% of its initial value, and was controlled after 2 days, 1, or 4 weeks, there were no significant variation with the first postoperative determination. Portal vein pressure, portal vein resistance did not present significant changes compared with the preoperative determination. Hepatic oxygen delivery, hepatic oxygen consumption and hepatic oxygen extraction ratio presented no significant changes compared with the preoperative determination in all groups. Concentration levels of serum GOT, GPT, total bile acid elevated significantly in group I, but in group II and III, there was no significant difference compared with the preoperative level. AKBR and mGOT were not significantly different compared with the preoperative level in all groups. Histologically, the liver structure, common bile duct and portal vein showed no ischemic change compared with the control biopsy in all groups. In conclusion, this study showed portal arterialization under the optimal arterio-portal shunt flow has beneficial effects on liver under hepatic arterial obstruction for 4 weeks.