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. 1997 Oct;12(5):427-32.
doi: 10.3346/jkms.1997.12.5.427.

Relationship of transforming growth factor beta 1 to angiogenesis in gastric carcinoma

Y H Choi  1 , K C Choi, Y E Park
Affiliations

Relationship of transforming growth factor beta 1 to angiogenesis in gastric carcinoma

Y H Choi et al. J Korean Med Sci. 1997 Oct.

Abstract

Transforming growth factor-beta (TGF-beta) comprises a group of multifunctional regulatory proteins, whose effects include angiogenesis. The expression of TGF-beta 1 in gastric carcinomas (70 cases) has been determined and related to pathological features and microvessel count by immunohistochemical staining for TGF-beta 1 and Factor VIII related antigen. Prominent reactivity for TGF-beta 1 was associated with the depth of invasion (r = 0.2; p < 0.05) and increased microvessel count (r = 0.5; p < 0.05). Also, the microvessel count had a significant correlation with invasiveness (r = 0.34; p < 0.05) and lymph node metastasis (r = 0.28; p < 0.05). These findings indicate that TGF-beta 1 may have a role in tumor invasion and angiogenesis.

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