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. 1997;76(9):1181-3.
doi: 10.1038/bjc.1997.530.

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833

J van Asperen  1 , O van Tellingen, A Sparreboom, A H Schinkel, P Borst, W J Nooijen, J H Beijnen
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Free PMC article

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833

J van Asperen et al. Br J Cancer. 1997.
Free PMC article

Abstract

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.

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