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. 1997;76(9):1181-3.
doi: 10.1038/bjc.1997.530.

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833

J van Asperen  1 , O van Tellingen, A Sparreboom, A H Schinkel, P Borst, W J Nooijen, J H Beijnen
Affiliations
Free PMC article

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833

J van Asperen et al. Br J Cancer. 1997.
Free PMC article

Abstract

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.

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References

    1. Mol Cell Biol. 1989 Mar;9(3):1346-50 - PubMed
    1. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2031-5 - PubMed
    1. Cancer Res. 1991 Aug 15;51(16):4226-33 - PubMed
    1. Int J Cancer. 1992 Feb 20;50(4):593-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11748-52 - PubMed