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Comparative Study
. 1997 Oct 29;239(3):905-10.
doi: 10.1006/bbrc.1997.7580.

Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1

K Tobiume  1 , T Inage, K Takeda, S Enomoto, K Miyazono, H Ichijo
Affiliations
Comparative Study

Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1

K Tobiume et al. Biochem Biophys Res Commun. .

Abstract

The mouse cDNA for apoptosis signal-regulating kinase 1 (ASK)1 was isolated. The overall amino acid sequence identity between the mouse and the human ASK1 was 91.9%. A database search revealed that the kinase domain of ASK1 is evolutionally well-conserved over species among nematode, fly, mouse and human. Northern blot analysis identified a 6-kb transcript of ASK1 which is expressed in the various mouse adult tissues including heart, brain, lung, liver and kidney. Immunohistochemical analysis of mouse embryos (17 days post coitum) revealed a localized expression of ASK1 in developing skin, cartilage and bone, suggesting a possible role for ASK1 in tissue development during embryogenesis as well as cytokine-induced apoptosis.

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