Behavioral regulation of gonadotropin-releasing hormone production

Abstract

In vertebrates reproductive readiness requires coordination between the sexes. Behavioral interactions with potential mates can initiate the neuroendocrine events that are required for successful copulation, ovulation, and fertilization. Regardless of the efferent pathway used, their targets are the neurons that produce and secrete gonadotropin-releasing hormone (GnRH). Several excellent animal models are currently under use to study the relationship between behavior and GnRH. In the musk shrew (Suncus murinus) starting 15 h after mating, prior to ovulation, GnRH-ir cell numbers are elevated along with GnRH content in brain and estradiol in plasma. Immunoreactive GnRH cell numbers also change in brains of female musk shrews sacrificed during, and directly after, brief interactions with males. These rapid changes in GnRH-ir cells are not correlated with measurable increases in GnRH content or elevations in plasma concentrations of estradiol. To determine which aspect(s) of the behavioral interaction is salient for the change in GnRH-ir, studies have been conducted in which interactions with males and their sensory cues were restricted during a 1-h interaction. In this study, behavioral interactions with an awake male behind a screen barrier resulted in a decrease in the numbers of GnRH-ir cells in the forebrain. Further studies with this animal model will help determine how behavioral inputs stimulate processing and release of GnRH.