Comparative Study
doi: 10.1128/AAC.41.11.2544.
Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins
Affiliations
- PMID: 9371364
- PMCID: PMC164159
- DOI: 10.1128/AAC.41.11.2544
Item in Clipboard
Comparative Study
Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins
Antimicrob Agents Chemother.
1997 Nov.
Abstract
MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumoniae isolates and 21 Enterobacter cloacae isolates with altered GyrA or altered GyrA and ParC ranged from < or =0.025 to 6.25 microg/ml and from 0.1 to 3.13 microg/ml, respectively. Based on the MICs at which 90% of the isolates were inhibited for these strains of K. pneumoniae and E. cloacae, DU-6859a exhibited 16- to 256-fold-greater activity than currently available fluoroquinolones.
Similar articles
-
In-vitro antimicrobial activity of HSR-903, a new fluoroquinolone, against clinical isolates of Klebsiella pneumoniae and Enterobacter cloacae with fluoroquinolone resistance-associated amino acid alterations in GyrA and ParC.J Antimicrob Chemother. 1997 Dec;40(6):907-9. doi: 10.1093/jac/40.6.907. J Antimicrob Chemother. 1997. PMID: 9462448 No abstract available.
-
Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Neisseria gonorrhoeae with genetic alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV.J Antimicrob Chemother. 1997 Feb;39(2):247-9. doi: 10.1093/jac/39.2.247. J Antimicrob Chemother. 1997. PMID: 9069547
-
Detection of mutations in the gyrA and parC genes in quinolone-resistant clinical isolates of Enterobacter cloacae.J Antimicrob Chemother. 1997 Oct;40(4):543-9. doi: 10.1093/jac/40.4.543. J Antimicrob Chemother. 1997. PMID: 9372424
-
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.Antimicrob Agents Chemother. 1999 Aug;43(8):2051-5. doi: 10.1128/AAC.43.8.2051. Antimicrob Agents Chemother. 1999. PMID: 10428935 Free PMC article.
-
Comparison of gyrA and parC mutations and resistance levels among fluoroquinolone-resistant isolates and laboratory-derived mutants of oral streptococci.J Antimicrob Chemother. 2000 Jun;45(6):771-5. doi: 10.1093/jac/45.6.771. J Antimicrob Chemother. 2000. PMID: 10837428
Cited by
-
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production.Antimicrob Agents Chemother. 2002 Dec;46(12):3926-32. doi: 10.1128/AAC.46.12.3926-3932.2002. Antimicrob Agents Chemother. 2002. PMID: 12435697 Free PMC article.
-
Genotypes of Klebsiella oxytoca isolates from patients with nosocomial pneumonia are distinct from those of isolates from patients with antibiotic-associated hemorrhagic colitis.J Clin Microbiol. 2014 May;52(5):1607-16. doi: 10.1128/JCM.03373-13. Epub 2014 Mar 5. J Clin Microbiol. 2014. PMID: 24599976 Free PMC article.
-
Alteration of GyrA amino acid required for ciprofloxacin resistance in Klebsiella pneumoniae isolates in China.Antimicrob Agents Chemother. 2008 Aug;52(8):2980-3. doi: 10.1128/AAC.00151-08. Epub 2008 May 27. Antimicrob Agents Chemother. 2008. PMID: 18505849 Free PMC article.
-
In vitro activities of sitafloxacin tested alone and in combination with rifampin, colistin, sulbactam, and tigecycline against extensively drug-resistant Acinetobacter baumannii.Int J Clin Exp Med. 2015 May 15;8(5):8135-40. eCollection 2015. Int J Clin Exp Med. 2015. PMID: 26221381 Free PMC article.
-
Sulbactam enhances the in vitro activity of sitafloxacin against extensively-drug resistant Acinetobacter baumannii.Exp Ther Med. 2018 Oct;16(4):3485-3491. doi: 10.3892/etm.2018.6630. Epub 2018 Aug 20. Exp Ther Med. 2018. PMID: 30233699 Free PMC article.
References
-
- Antimicrob Agents Chemother. 1993 Apr;37(4):839-45 - PubMed
-
- Antimicrob Agents Chemother. 1993 Apr;37(4):696-701 - PubMed
-
- Antimicrob Agents Chemother. 1995 Jan;39(1):170-4 - PubMed
-
- Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11801-5 - PubMed
-
- Antimicrob Agents Chemother. 1995 Jul;39(7):1467-71 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
