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Comparative Study
. 1997 Nov;41(11):2544-6.
doi: 10.1128/AAC.41.11.2544.

Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins

T Deguchi  1 , M Yasuda, KawamuraT, M Nakano, S Ozeki, E Kanematsu, Y Nishino, Y Kawada
Affiliations
Comparative Study

Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins

T Deguchi et al. Antimicrob Agents Chemother. 1997 Nov.

Abstract

MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumoniae isolates and 21 Enterobacter cloacae isolates with altered GyrA or altered GyrA and ParC ranged from < or =0.025 to 6.25 microg/ml and from 0.1 to 3.13 microg/ml, respectively. Based on the MICs at which 90% of the isolates were inhibited for these strains of K. pneumoniae and E. cloacae, DU-6859a exhibited 16- to 256-fold-greater activity than currently available fluoroquinolones.

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References

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