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Comparative Study
. 1997 Nov;41(11):2547-9.
doi: 10.1128/AAC.41.11.2547.

Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244

L Bret  1 , E B Chaibi, C Chanal-Claris, D Sirot, R Labia, J Sirot
Affiliations
Comparative Study

Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244

L Bret et al. Antimicrob Agents Chemother. 1997 Nov.

Abstract

A novel inhibitor-resistant TEM (IRT) beta-lactamase was detected in an Escherichia coli isolate resistant to amoxicillin-clavulanate and susceptible to cephalothin. The substrate and inhibitor profiles of this beta-lactamase were similar to those of IRT-1 and IRT-2. The novel IRT's bla gene was sequenced, and the deduced amino acid sequence showed the amino acid replacement Arg for His-244 of the TEM-1 sequence. Substitutions for Arg-244 have been reported in three TEM-1 mutants: IRT-1 (which corresponds to TEM-31) (Cys), IRT-2/TEM-30 (Ser), and TEM-41 (Thr). We designated this novel beta-lactamase, which corresponds to TEM-51, IRT-15.

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