doi: 10.1016/0002-9149(76)90070-9.
Influence of dobutamine on hemodynamics and coronary blood flow in patients with and without coronary artery disease
- PMID: 937182
- DOI: 10.1016/0002-9149(76)90070-9
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Influence of dobutamine on hemodynamics and coronary blood flow in patients with and without coronary artery disease
Am J Cardiol.
1976 Jul.
Abstract
The influence of dobutamine on hemodynamics and coronary blood flow was studied in patients after routine cardiac catheterization. The data demonstrated that dobutamine is a powerful inotropic agent at a dose that has a relatively small influence on heart rate. In patients without coronary artery disease dobutamine greatly increased coronary arterial perfusion. In patients with severe coronary artery diseases dobutamine resulted in a much smaller increase in coronary perfusion, and the pattern of perfusion became more inhomogeneous. The results suggest that dobutamine has a potential inotropic value but raise concern about its influence on regional myocardial perfusion in patients with serious coronary artery disease.
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