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Case Reports
. 1997 Nov;49(5):1442-4.
doi: 10.1212/wnl.49.5.1442.

Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid

D S Chattergoon  1 , M A McGuigan, G Koren, P Hwang, S Ito
Affiliations
Case Reports

Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid

D S Chattergoon et al. Neurology. 1997 Nov.

Abstract

Two children developed multiorgan dysfunction with disseminated intravascular coagulation 9 days after lamotrigine was added to their antiepileptic therapy, which included valproic acid. During the episodes, rhabdomyolysis was detected in one of them, while being seizure-free, suggesting that this adverse reaction may involve muscular tissue.

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