Diagnosis, clinical course, and management of idiopathic thrombocytopenic purpura

Abstract

Idiopathic thrombocytopenic purpura is a common acquired bleeding disorder. However, the diagnosis is often uncertain because there are no specific tests that define idiopathic thrombocytopenic purpura, and management decisions are often difficult because there are no firm data to define the clinical course and to estimate the risks of major bleeding and death. Because the incidence of idiopathic thrombocytopenic purpura is greatest in young women, its occurrence during pregnancy is a frequent problem, with specific issues related to the anticipated route of delivery and the risks for neonatal thrombocytopenia. To address these unresolved issues, the American Society of Hematology established a panel to develop a practice guideline for idiopathic thrombocytopenic purpura. The data from this recently published document and its recommendations are summarized in this review.