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. 1979 Oct;14(2-3):177-82.
doi: 10.1016/0304-3940(79)96144-5.

The presynaptic stimulating effect of acetylcholine on dopamine release is suppressed during activation of nigro-striatal dopaminergic neurons in the cat

M F Giorguieff-Chesselet, M L Kemel, J Glowinski

The presynaptic stimulating effect of acetylcholine on dopamine release is suppressed during activation of nigro-striatal dopaminergic neurons in the cat

M F Giorguieff-Chesselet et al. Neurosci Lett. 1979 Oct.

Abstract

Acetylcholine (ACh) (10(-5) M) in the presence of eserine (2 . 10(-4) M) stimulated the release of [3H]dopamine (DA) continuously formed from [3H]tyrosine, when delivered to a push-pull cannula implanted in the left caudate nucleus of halothane anaesthetized cats. This effect was transient and followed by a second increase in [3H]DA release after removal of ACh and eserine. These changes in [3H]DA release during and after ACh application were no longer seen during activation of the dopaminergic neurons by continuous delivery of substance P to the ipsilateral substantia nigra (SN). These results indicate that the presynaptic regulation of DA release by ACh is dependent on the rate of firing of nigro-striatal dopaminergic neurons.

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