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. 1997 Nov 28;278(5343):1638-41.
doi: 10.1126/science.278.5343.1638.

Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway

C W Chow  1 , M Rincón, J Cavanagh, M Dickens, R J Davis
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Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway

C W Chow et al. Science. .

Abstract

The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells. NFAT activation is mediated in part by induced nuclear import. This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin. The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites. Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4. In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4. These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.

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