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Clinical Trial
. 1997 Sep;77(2):F119-22.
doi: 10.1136/fn.77.2.f119.

Cisapride reduces neonatal postoperative ileus: randomised placebo controlled trial

A Lander  1 , R Redkar, G Nicholls, A Lawson, S R Choudhury, J J Corkery, P Gornall, R G Buick, I W Booth
Affiliations
Clinical Trial

Cisapride reduces neonatal postoperative ileus: randomised placebo controlled trial

A Lander et al. Arch Dis Child Fetal Neonatal Ed. 1997 Sep.

Abstract

Aim: To assess the efficacy of cisapride in reducing ileus persisting to the tenth postoperative day after neonatal abdominal surgery.

Methods: A prospective, randomised, double blind trial comparing rectal cisapride (1.4-2.3 mg/kg/day) with placebo over seven days was undertaken in 33 neonates.

Results: Seven of 12 (58%) patients receiving placebo and eight of 11 (73%) receiving cisapride achieved a first sustained feed during treatment. Of those receiving cisapride, the first sustained feed occurred at 2.3 days (SEM 0.6) compared with 4.7 days (SEM 0.8) with placebo. By the seventh day the mean daily net enteral balance was 69 (SEM 18) ml/kg in the cisapride subgroup and 17 (SEM 8) ml/kg for those receiving placebo. Stool was passed on 6.3 (SEM 0.4) treatment days in the cisapride subgroup compared with 4.1 (SEM 1.0) treatment days in the placebo subgroup.

Conclusion: Cisapride is effective in neonates with a prolonged ileus after abdominal surgery.

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Figures

Figure 1
Figure 1
Graph of mean net enteral balance in ml/kg/days for days 1-7 for cisapride • (1.4-2.3 mg/kg/day) (n =11) or placebo ∘ (n = 12) in 23 neonates. Day 0 is the 10th postoperative day after abdominal surgery with persisting ileus. Error bars are standard errors. *P < 0.04; ** P = 0.02; t test.
Figure 2
Figure 2
Scattergram of time from start of treatment to first sustained feed for neonates receiving rectal cisapride mean 2.3 days (SEM 0.6) and placebo mean 4.7 days (SEM 0.8) P < 0.029; two tailed t test.
Figure 3
Figure 3
Graph of mean net enteral balance in ml/kg/day for days 1-7 for neonates receiving cisapride • (1.4-2.3 mg/kg/day) (n = 8) or placebo ∘ (n = 7) in 15 neonates who attained a first sustained feed. Day 0 is the 10th postoperative day after abdominal surgery with persisting ileus. Error bars are standard errors. *P < 0.04; ** P < 0.02; t test.
Figure 4
Figure 4
Scattergram of number of days on which stool was passed in neonates who attained a first sustained feed on rectal cisapride mean 6.3 days (SEM 0.4) and placebo mean 4.1 days (SEM 1.0); P = 0.059, two tailed t test.
See this image and copyright information in PMC

Comment in

  • The use of cisapride in neonates.
    Davies MW. Davies MW. Arch Dis Child Fetal Neonatal Ed. 2000 Jul;83(1):F75. doi: 10.1136/fn.83.1.f74c. Arch Dis Child Fetal Neonatal Ed. 2000. PMID: 10917723 Free PMC article. No abstract available.

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