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. 1976 Jun;9(6):925-7.
doi: 10.1128/AAC.9.6.925.

Concentrations of gentamicin and amikacin in human kidneys

C Q Edwards, C R Smith, K L Baughman, J F Rogers, P S Lietman

Concentrations of gentamicin and amikacin in human kidneys

C Q Edwards et al. Antimicrob Agents Chemother. 1976 Jun.

Abstract

High kidney concentrations of gentamicin or amikacin, measured by an enzymological assay, were found in 9 of 10 patients who died during therapy with these aminoglycosides. Renal cortical concentrations of gentamicin ranged from 140 to 540 mug/g of tissue, with medullary levels of 128 to 230 mug/g. Concentrations of amikacin ranged from 365 to 1,030 mug/g in the cortex and from 270 to 718 mug/g in the medulla. The only patient with low kidney concentrations was an infant who received a single dose of gentamicin. Tissue levels were high in patients with both normal and abnormal renal function. Our results indicate that gentamicin and amikacin are concentrated in renal cortical and medullary tissue.

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References

    1. J Lab Clin Med. 1975 Aug;86(2):213-20 - PubMed
    1. Arch Intern Med. 1976 Feb;136(2):172-7 - PubMed
    1. Antimicrob Agents Chemother. 1973 Oct;4(4):497-9 - PubMed

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