Cell-cycle signaling: Atm displays its many talents
- PMID: 9382823
- DOI: 10.1016/s0960-9822(06)00406-4
Cell-cycle signaling: Atm displays its many talents
Abstract
The discovery of multiple signaling cascades downstream of Atm may lead to a clearer understanding of the diverse defects seen in ataxia-telangiectasia. These pathways - which include evolutionarily conserved Chk1 and Atr, and non-conserved p21, p53 and AbI - guard genomic integrity after DNA damage.
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