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Review
. 1995 Jan;2(1):1-5.
doi: 10.1016/1074-5521(95)90074-8.

The chemistry of scrapie infection: implications of the 'ice 9' metaphor

P T Lansbury Jr  1 , B Caughey
Affiliations
Review

The chemistry of scrapie infection: implications of the 'ice 9' metaphor

P T Lansbury Jr et al. Chem Biol. 1995 Jan.

Abstract

The transmissible spongiform encephalopathies pose an increasing problem for animal, and perhaps human, health. The infectious agent seems to lack a nucleic acid component, posing the question of how it can reproduce. A model of reproduction by nucleated polymerization suggests a number of novel approaches to the problem.

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