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Review
. 1995 Sep;1(3):149-63.

Molecular biology of glucocerebrosidase and the treatment of Gaucher disease

J A Barranger  1 , J Tomich, S Weiler, S Sakallah, C Sansieri, T Mifflin, A Bahnson, F S Wei, J F Wei, M Vallor, et al.
Affiliations
  • PMID: 9384672
Review

Molecular biology of glucocerebrosidase and the treatment of Gaucher disease

J A Barranger et al. Cytokines Mol Ther. 1995 Sep.

Abstract

The inherited deficiency of glucocerebrosidase results in a group of sphingolipid storage disorders referred to collectively as Gaucher disease. Study of the biochemistry and cell biology of glucocerebrosidase has made possible an effective enzyme replacement therapy for the disease. Definition of the molecular genetics of glucocerebrosidase has improved diagnostic capabilities and presents the exciting possibility of a cure through gene therapy.

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