Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997;14(1):5-11.
doi: 10.1007/BF02478862.

Neuronal differentiation of human neuroblastoma SH-SY5Y cells by gangliosides

M C Lee  1 , B W Kim, J S Kim, J S Lee, K S Kim, J H Lee, J H Nam, S M Rowe, S U Kim
Affiliations

Neuronal differentiation of human neuroblastoma SH-SY5Y cells by gangliosides

M C Lee et al. Brain Tumor Pathol. 1997.

Abstract

Exogenous administration of gangliosides induced neuronal differentiation with prominent neuritogenesis in human neuroblastoma SH-SY5Y cells in vitro. Neuritogenesis was characterized by ruffling of the cell membrane, the development of lamellipodia and filopodia, and the subsequent elongation and branching of the neurites ultrastructurally. Both axons and neurites were identified. Increased numbers of cell organelles in the neurites and cell bodies were noted. Nonsynaptic contacts and gap junctions formed between neurites or between each neurite and cell body. These findings could be implicated in histopathologic changes from neuroblastoma to ganglioneuroblastoma.

PubMed Disclaimer

Publication types

LinkOut - more resources