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. 1976 Jul;16(7):771-8.
doi: 10.1016/S0006-3495(76)85727-X.

Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state

C L Schauf, T L Pencek, F A Davis

Slow sodium inactivation in Myxicola axons. Evidence for a second inactive state

C L Schauf et al. Biophys J. 1976 Jul.

Abstract

Sodium inactivation and reactivation have been examined in voltage-clamped Myxicola axons after long-lasting membrane depolarizations produced either directly by changes in holding potential or indirectly by elevation of external K+ concentration. The results suggest the existence of a second inactivated state of the sodium channel with associated voltage-dependent rate constants at least two orders of magnitude lower than those of the fast inactivation process commonly examined. No specific influence of external [K+] on slow Na+ inactivation could be detected.

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