[Pathology of endothelium, extracellular matrix and smooth muscle in gastric coronary vein of cirrhotic patients]

Abstract

Immunohistochemical stain was used to observe the pathology of endothelium, extracellular matrix (ECM), vascular smooth muscle cell (VSMC) in gastric coronary vein of 30 cirrhotic patients and 10 controls. There was widespread destruction to endothelium, intravenous thrombosis, aggregation of pericyte, smooth muscle hyperplasia, and increased FN, LN, collagen IV and smooth muscle actin in the wall of the coronary vein in cirrhotic patients. The thickness of the wall and its smooth muscle were 3.07 +/- 1.03 mm and 2.31 +/- 0.76 mm respectively in cirrhotic patients, and 1.65 +/- 0.49 mm and 0.88 +/- 0.20 mm in non-cirrhotic patients (P < 0.01). Based on these observations a new concept of portal hypertensive vasculopathy was put forward.