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Clinical Trial
. 1997 Nov 15;80(10):1391-4.
doi: 10.1016/s0002-9149(97)00695-4.

Effects of lovastatin on the immune system

M F Muldoon  1 , J D Flory, A Marsland, S B Manuck, T L Whiteside, B Rabin
Affiliations
Clinical Trial

Effects of lovastatin on the immune system

M F Muldoon et al. Am J Cardiol. .

Abstract

Laboratory investigations have demonstrated that blockade of HMG-CoA reductase in vitro reduces lymphocyte proliferation in response to mitogens as well as other facets of the immune system, such as natural killer cell cytotoxicity. However, in this randomized and double-blind clinical investigation, treatment with 20-mg lovastatin for 6 months did not significantly alter several enumerative and functional characteristics of circulating immune cells.

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