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. 1997 Dec 5;278(5344):1809-12.
doi: 10.1126/science.278.5344.1809.

Multistep control of pituitary organogenesis

H Z Sheng  1 , K Moriyama, T Yamashita, H Li, S S Potter, K A Mahon, H Westphal
Affiliations

Multistep control of pituitary organogenesis

H Z Sheng et al. Science. .

Abstract

Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps-first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.

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