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Review
. 1997 Nov;24(14):2099-104.

[Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer--results of a randomized trial]

[Article in Japanese]
T Kaneta  1 , Y Takai, K Nemoto, Y Kakuto, Y Ogawa, H Ariga, S Maruoka, T Ishibashi, Y Hosoi, S Yamada
Affiliations
  • PMID: 9388519
Review

[Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer--results of a randomized trial]

[Article in Japanese]
T Kaneta et al. Gan To Kagaku Ryoho. 1997 Nov.

Abstract

Between 1994 and 1996, 24 patients with esophageal carcinoma were entered in a randomized clinical trial comparing radiotherapy (RT) only (arm A) versus RT and a daily low dose of CDDP (5 mg/m2) (arm B). For arm B group, CDDP was injected within 30 min after irradiation. All patients were irradiated with a total dose of 60 Gy /30fr. at first, and some patients were boosted. An overall response rate of 75.0% (complete response rate of 25.0%) was observed in arm A and 91.7% (complete response rate of 16.7%) in arm B, respectively. The survival rate at 1 year was 23.8% in arm A and 40.0% in arm B. Median survival time was 7 months in arm A and 9 months in arm B. Toxicity was acceptable and no significant difference was noted between arm A and arm B.

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