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. 1997 Sep;50(9):769-70.
doi: 10.1136/jcp.50.9.769.

Helicobacter pylori does not release cysteamine into gastric juice

M B Leonard  1 , W D Neithercut, D Gillen, K E McColl
Affiliations

Helicobacter pylori does not release cysteamine into gastric juice

M B Leonard et al. J Clin Pathol. 1997 Sep.

Abstract

Aim: To determine whether Helicobacter pylori releases cysteamine into gastric juice as cysteamine is known to be ulcerogenic.

Methods: Samples of fasting gastric juice were collected from 22 individuals (four women); 10 subjects were H pylori negative. The presence of infection was confirmed by examination and culture of gastric biopsies. Cysteamine in gastric juice was measured by reversed phase gradient high performance liquid chromatography with a detection limit of 10 mumol/l.

Results: Cysteamine was not detected in any of the gastric juice samples or in extracts of cultured H pylori.

Conclusions: If H pylori produces cysteamine then the amounts produced are insignificant and are unlikely to explain the association between H pylori infection and the development of duodenal ulcer disease.

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