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Case Reports
. 1997 Oct;137(4):605-8.
doi: 10.1111/j.1365-2133.1997.tb03795.x.

Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome

V Descamps  1 , F Bouscarat, S Laglenne, E Aslangul, B Veber, D Descamps, J L Saraux, M J Grange, M Grossin, E Navratil, B Crickx, S Belaich
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Case Reports

Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome

V Descamps et al. Br J Dermatol. 1997 Oct.

Abstract

Viral infections are thought to play a part in some cutaneous drug reactions. Human herpesvirus 6 (HHV6), which is the agent of exanthema subitum (sixth disease), has never been implicated in a drug reaction. We report a patient with severe phenobarbital-induced anticonvulsant hypersensitivity syndrome in whom a fulminant haemophagocytic syndrome was associated with HHV6 infection. We discuss the possible role of HHV6 in this reactive condition.

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