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. 1997 Nov;7(5):641-51.
doi: 10.1016/s1074-7613(00)80385-4.

A new MHC locus that influences class I peptide presentation

W A Simmons  1 , D C Roopenian, S G Summerfield, R C Jones, B Galocha, G J Christianson, S D Maika, M Zhou, S J Gaskell, R S Bordoli, H L Ploegh, C A Slaughter, K F Lindahl, R E Hammer, J D Taurog
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Free article

A new MHC locus that influences class I peptide presentation

W A Simmons et al. Immunity. 1997 Nov.
Free article

Retraction in

  • A new MHC locus that influences class I peptide presentation.
    Taurog JD, Lindahl KF, Hammer RE, Slaughter CA, Maika SD, Zhou M, Roopenian DC, Christianson GJ, Gaskell SJ, Jones RC, Bordoli R, Ploegh HL, Galocha B, Summerfield SG. Taurog JD, et al. Immunity. 1999 Oct;11(4):following 506. doi: 10.1016/s1074-7613(07)00041-6. Immunity. 1999. PMID: 10576912 No abstract available.

Abstract

We have investigated the HLA-B27-restricted CTL response to HY minor histocompatibility antigens in rats and mice transgenic for HLA-B27 and human beta2-microglobulin. A polymorphism was found at a locus within the H2 complex, producing two distinct but overlapping sets of B27-presented HY peptides. The locus, named Cim2, mapped between the K and Pb loci, and its product is therefore distinct from TAP, LMP, and tapasin. Identical findings in rats and mice, including identical HY peptide sequences and the failure of a rat Tap2A transgene to alter CTL recognition, suggest that a homologous locus with similar polymorphism exists in the rat. Cim2, or a closely linked locus, was found to exert a broad effect on peptide loading of both HLA-B27 and mouse class I alleles. The data thus establish a strong, previously unrecognized MHC-encoded influence on the class I antigen pathway.

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Comment in

  • Findings.
    [No authors listed] [No authors listed] NIH Guide Grants Contracts (Bethesda). 2000 Sep 12:OD-00-052. NIH Guide Grants Contracts (Bethesda). 2000. PMID: 12458560 Free PMC article. No abstract available.

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