Interference of peptides and specific antibodies with the function of the Actinobacillus pleuropneumoniae transferrin-binding protein
- PMID: 9393838
- PMCID: PMC175771
- DOI: 10.1128/iai.65.12.5346-5348.1997
Interference of peptides and specific antibodies with the function of the Actinobacillus pleuropneumoniae transferrin-binding protein
Abstract
Multiple-antigenic peptides (MAPs) containing transferrin-binding domains of the Actinobacillus pleuropneumoniae serotype 7-derived transferrin-binding protein (TfbA) (K. Strutzberg, L. von Olleschik, B. Franz, C. Pyne, M. A. Schmidt, and G.-F. Gerlach, Infect. Immun. 63:3846-3850, 1995) were constructed. It was found that the MAPs inhibited transferrin binding of the recombinant TfbA protein, whereas antibodies directed against transferrin-binding domains failed to do so.
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