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Review
. 1997 Nov 3;417(1):1-5.
doi: 10.1016/s0014-5793(97)01259-3.

Alu sequences

A J Mighell  1 , A F Markham, P A Robinson
Affiliations
Free article
Review

Alu sequences

A J Mighell et al. FEBS Lett. .
Free article

Abstract

Alu sequences are frequently encountered during study of human genomic nucleic acid and form a major component of repetitive DNA. This review describes the origin of Alu sequences and their subsequent amplification and evolution into distinct subfamilies. In recent years a number of different functional roles for Alu sequences have been described. The multiple influences of Alu sequences on RNA polymerase II-mediated gene expression and the presence of Alu sequences in RNA polymerase III-generated transcripts are discussed.

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