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Review
. 1997 Dec;26(6):1667-77.
doi: 10.1002/hep.510260641.

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

P J Meier  1 , U Eckhardt, A Schroeder, B Hagenbuch, B Stieger
Affiliations
Review

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

P J Meier et al. Hepatology. 1997 Dec.

Abstract

The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.

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