Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Nov;42(11):2378-83.
doi: 10.1023/a:1018847608184.

Submandibular gland peptide-T (SGP-T) inhibits intestinal anaphylaxis

R Mathison  1 , D Tan, M Oliver, D Befus, B Scott, J S Davison
Affiliations

Submandibular gland peptide-T (SGP-T) inhibits intestinal anaphylaxis

R Mathison et al. Dig Dis Sci. 1997 Nov.

Abstract

A novel peptide, submandibular gland peptide-T (SGP-T), which reduces allergen-induced hypotension, was examined for effects on intestinal anaphylaxis. Hooded-Lister rats were sensitized to egg albumin and prepared for the measurement of in vivo myoelectric activity of the jejunum. The disruption of migrating myoelectric complexes (MMCs) that occurs upon intraluminal, duodenal challenge with antigen of sensitized rats was inhibited by 75% upon intravenous treatment with 100 micrograms/kg of SGP-T. In addition, SGP-T reduced the number of rats experiencing anaphylactic diarrhea and disrupted MMCs, but the peptide did not alter antigen-provoked release of rat mast cell protease II. The mechanism of action of SGP-T remains to be determined, but it apparently does not act directly on mast cells to exert its antianaphylactic action. These results emphasize that modulation of immediate hypersensitivity reactions is only one of several gastrointestinal activities that are affected by growth factors and peptides released from salivary glands.

PubMed Disclaimer

References

    1. Trends Pharmacol Sci. 1994 Sep;15(9):324-32 - PubMed
    1. J Manipulative Physiol Ther. 1992 Jan;15(1):10-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8553-7 - PubMed
    1. Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 2):S72-6 - PubMed
    1. J Can Dent Assoc. 1992 Mar;58(3):217-21 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources