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Review
. 1997:640:153-4.

Exhausted subjects, exhausted systems

A Appels  1
Affiliations
  • PMID: 9401630
Review

Exhausted subjects, exhausted systems

A Appels. Acta Physiol Scand Suppl. 1997.

Abstract

A state of 'vital exhaustion', characterized by unusual tiredness, increased irritability and feelings of demoralization has been found to preceed the onset of myocardial infarction and to increase the risk of a new coronary event after angioplasty. Probably this state reflects a decreased activity of the hypothalamic-pituitary-adrenal axis as part of an homeostatic reaction to prolonged stress and inflammation.

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