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Case Reports
. 1997 Dec;124(6):843-4.
doi: 10.1016/s0002-9394(14)71705-2.

Retinal toxicity associated with occupational exposure to the fish anesthetic MS-222

P S Bernstein  1 , K B Digre, D J Creel
Affiliations
Case Reports

Retinal toxicity associated with occupational exposure to the fish anesthetic MS-222

P S Bernstein et al. Am J Ophthalmol. 1997 Dec.

Abstract

Purpose: To report a case of retinopathy associated with chronic occupational exposure to ethyl-m-aminobenzoic acid methanesulfonate (MS-222), a retinotoxic fish anesthetic.

Method: Case report with electroretinograms to document changes in visual electrophysiology.

Results: An ichthyologist with a long history of skin exposure to MS-222 was initially examined for decreased vision, photophobia, and photopsia. His electroretinogram abnormalities were similar to those seen in animal models of acute MS-222 toxicity. After terminating MS-222 contact for 7 months, his vision returned to normal, and his electroretinogram improved.

Conclusion: Individuals with occupational exposure to MS-222 should exercise caution to avoid systemic absorption of this retinotoxic compound.

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