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Clinical Trial
. 1997;17(1):11-5.

Efficacy of alpha,beta-arteether in acute uncomplicated P. falciparum malaria

N Valecha  1 , S Gupta, D Usha, S Biswas, A Sharma, T Adak, O P Asthana, V P Sharma
Affiliations
  • PMID: 9403348
Clinical Trial

Efficacy of alpha,beta-arteether in acute uncomplicated P. falciparum malaria

N Valecha et al. Int J Clin Pharmacol Res. 1997.

Abstract

A phase-III clinical trial was conducted in 50 patients (42M + 8F) with acute uncomplicated falciparum malaria from Delhi during the period of September to November 1995. Their mean age was 27.2 years, and the mean parasitaemia on day 0 was 0.65%. Patients were hospitalized and treated with a new ethyl derivative of artemisinin developed at CDRI called alpha, beta-arteether, at the dosage of 150 mg l/M for three consecutive days. Peripheral smears were examined every day for 4 days and then weekly up to 28 days. The results of the study showed that the mean parasite and fever clearance times were respectively 19.94 +/- 6.87 and 37.81 +/- 21.67 hours. Within 48 h, 70% of the cases became afebrile and the peripheral smear was negative in 100% of the cases. The drug was well tolerated. Three cases (6%) had recrudescence within 28 days. It is concluded that alpha, beta-arteether is a safe, effective and rapidly acting antimalarial.

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