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Comparative Study
. 1997 Dec;18(6):580-93; discussion 661-6.
doi: 10.1016/s0197-2456(97)00051-2.

Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis

J M Pogue  1 , S Yusuf
Affiliations
Comparative Study

Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis

J M Pogue et al. Control Clin Trials. 1997 Dec.

Abstract

We propose the adaptation of classical monitoring boundaries for use in cumulative meta-analysis as guidelines for deciding when accumulating evidence is statistically significant and medically convincing. The interpretation of information from a randomized controlled trial is compared with that from a meta-analysis. The concept of optimal information size for a meta-analysis is developed and used to adapt monitoring boundaries to cumulative meta-analysis.

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