Descriptive definition and historic aspects of sarcoidosis

Abstract

Sarcoidosis is set within the framework of a large family of granulomatous disorders, so it has many mimics. Granuloma formation is defined with its immunologic basis. The criteria of activity of sarcoidosis are included in the broadly based definition. Future knowledge will derive from basic immunology and molecular biology. Historic aspects are based on pioneers, who have died, and their seminal contributions. Evolution of knowledge derives from information gained at international conferences and from our biennial journal, "Sarcoidosis, Vasculitis and Diffuse Lung Diseases."