Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997 Dec;11(6):470-9.
doi: 10.2165/00002512-199711060-00006.

Clinical pharmacokinetics of nifedipine. Implications for the care of the elderly

H L Elliott  1 , P A Meredith
Affiliations
Review

Clinical pharmacokinetics of nifedipine. Implications for the care of the elderly

H L Elliott et al. Drugs Aging. 1997 Dec.

Abstract

Nifedipine, the prototype for the dihydropyridine class of calcium antagonists, has been available for 20 years and its efficacy as a vasodilator and an antihypertensive agent is well recognised. The development of the so-called nifedipine gastrointestinal therapeutic system (GITS), which allows once-daily administration, has modified and improved the overall therapeutic profile of nifedipine to such a significant extent that it might almost be considered a new drug entity. The nifedipine GITS is associated with distinct improvements in terms of patient compliance and convenience, and a reduced incidence of adverse effects. With regard to the care of the elderly, this 'new' drug offers the prospect of a well tolerated and effective treatment without major cost implications.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. J Hypertens. 1995 Jun;13(6):571-9 - PubMed
    1. Br J Clin Pharmacol. 1988 Mar;25(3):297-305 - PubMed
    1. J Hypertens. 1996 Oct;14(10):1237-45 - PubMed
    1. Hypertension. 1988 Oct;12(4):443-9 - PubMed
    1. Clin Pharmacol Ther. 1992 Jul;52(1):80-9 - PubMed

LinkOut - more resources