Review
doi: 10.1046/j.1365-2443.1997.1450343.x.
Phage DNA packaging
Affiliations
- PMID: 9413995
- DOI: 10.1046/j.1365-2443.1997.1450343.x
Item in Clipboard
Review
Phage DNA packaging
Genes Cells.
1997 Sep.
Free article
Abstract
Phage DNA packaging occurs by DNA translocation into a preformed protein shell--a prohead--with the aid of a packaging enzyme or a terminase. The packaging enzyme is composed of two subunits: the large subunit has ATP-binding, prohead binding, and DNA cleavage activities, and the small subunit is a DNA binding protein. DNA translocation is driven by ATP hydrolysis. In general, phage DNA replication mechanisms lead to the accumulation of concatemers. Concatemers are processed to mature DNA during and depending upon DNA packaging. This review will focus on the molecular mechanism of concatemer processing and the coupling of ATP hydrolysis to DNA translocation.
Similar articles
-
The bacteriophage DNA packaging machine.Adv Exp Med Biol. 2012;726:489-509. doi: 10.1007/978-1-4614-0980-9_22. Adv Exp Med Biol. 2012. PMID: 22297528 Review.
-
Structural and functional domains of the large subunit of the bacteriophage T3 DNA packaging enzyme: importance of the C-terminal region in prohead binding.J Mol Biol. 1995 Feb 3;245(5):635-44. doi: 10.1006/jmbi.1994.0052. J Mol Biol. 1995. PMID: 7844832
-
An ATP hydrolysis sensor in the DNA packaging motor from bacteriophage T4 suggests an inchworm-type translocation mechanism.J Mol Biol. 2007 May 25;369(1):79-94. doi: 10.1016/j.jmb.2007.03.019. Epub 2007 Mar 15. J Mol Biol. 2007. PMID: 17428497
-
Virus DNA packaging: the strategy used by phage lambda.Mol Microbiol. 1995 Jun;16(6):1075-86. doi: 10.1111/j.1365-2958.1995.tb02333.x. Mol Microbiol. 1995. PMID: 8577244 Review.
-
DNA packaging and cutting by phage terminases: control in phage T4 by a synaptic mechanism.Bioessays. 1995 Dec;17(12):1025-30. doi: 10.1002/bies.950171206. Bioessays. 1995. PMID: 8634063 Review.
Cited by
-
Lysis to Kill: Evaluation of the Lytic Abilities, and Genomics of Nine Bacteriophages Infective for Gordonia spp. and Their Potential Use in Activated Sludge Foam Biocontrol.PLoS One. 2015 Aug 4;10(8):e0134512. doi: 10.1371/journal.pone.0134512. eCollection 2015. PLoS One. 2015. PMID: 26241321 Free PMC article.
-
Evolution and the complexity of bacteriophages.Virol J. 2007 Mar 13;4:30. doi: 10.1186/1743-422X-4-30. Virol J. 2007. PMID: 17355641 Free PMC article.
-
Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28.J Virol. 2003 Jun;77(11):6351-8. doi: 10.1128/jvi.77.11.6351-6358.2003. J Virol. 2003. PMID: 12743292 Free PMC article.
-
A Perspective on Studies of Phage DNA Packaging Dynamics.Int J Mol Sci. 2022 Jul 16;23(14):7854. doi: 10.3390/ijms23147854. Int J Mol Sci. 2022. PMID: 35887200 Free PMC article.
-
Genome sequence and characterization of the Tsukamurella bacteriophage TPA2.Appl Environ Microbiol. 2011 Feb;77(4):1389-98. doi: 10.1128/AEM.01938-10. Epub 2010 Dec 23. Appl Environ Microbiol. 2011. PMID: 21183635 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
