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. 1997 Nov;41(5):600-5.
doi: 10.1136/gut.41.5.600.

Oesophageal motor responses to gastro-oesophageal reflux in healthy controls and reflux patients

A Anggiansah  1 , G Taylor, R E Marshall, N F Bright, W A Owen, W J Owen
Affiliations

Oesophageal motor responses to gastro-oesophageal reflux in healthy controls and reflux patients

A Anggiansah et al. Gut. 1997 Nov.

Abstract

Aims: To compare oesophageal motor responses to gastro-oesophageal reflux (GOR) in 16 healthy controls (group 1) and 25 reflux patients, 15 without (group 2) and 10 with (group 3) oesophagitis.

Methods: All subjects underwent 24 hour ambulatory oesophageal pH measurements (5 cm above the lower oesophageal sphincter (LOS)) combined with pressure monitoring (5, 10, and 15 cm above the LOS for oesophageal body motility and 27 cm above the LOS for voluntary swallow detection). Contraction patterns (peristaltic, simultaneous, isolated, mixed type, and non-transmitted swallows) and peristaltic contraction wave characteristics (amplitude, duration, and velocity) during GOR were compared in the three groups.

Results: The average number of motor activities per minute was significantly higher in group 1 (p < 0.05). In all groups, the most common motor contraction pattern was peristaltic. The percentage of peristaltic activity per subject was significantly higher in group 1 (p < 0.05). There were no significant differences in other contraction patterns among the three groups (p > 0.05). Of the peristaltic contraction wave characteristics there were no significant differences in any parameters (amplitude, duration, and velocity) among the three groups (p > 0.05). The average pH increment in response to motor activities was significantly higher in group 1 (p < 0.05).

Conclusions: Motor responses to GOR were found to be predominantly primary peristaltic in all groups. During GOR, reflux patients have less frequent activity, a smaller proportion of activity is peristaltic, and the average pH increment in response to motor activities is reduced compared with controls.

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Figures

Figure 1
Figure 1
: Percentages of different motor activities during GOR in the upright (A) and supine (B) period.
Figure 2
Figure 2
: Percentages of different primary (A) and secondary (B) activities during GOR.
Figure 3
Figure 3
: Comparison of the mean (SD) percentages of each of the five types of motor activity (peristaltic, simultaneous, isolated, mixed type contractions, and non-transmitted swallow) between the three groups. *p<0.05 group 1 v groups 2 and 3.
Figure 4
Figure 4
: Mean (SD) pH increments in response to each type of motor activity during the total period.
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